e-cadherin promoter methylation comparison and correlation with the pathological features of the squamous cell carcinoma of esophagus in the high risk region
نویسندگان
چکیده
e-cadherin is among tumor suppressor genes which mostly subjects to the down-regulation in squamous cell carcinoma of esophagus (scce). the gene is tightly associated with the tumor invasion and metastasis in multiple human cancers, especially scce. cpg islands’ methylation in the promoter region of e-cadherin is among the mechanisms that have been suggested for the e-cadherin silencing, however, little is known regarding (scce) in the high risk region of the world. to establish a correlation between e-cadherin promoter methylation with the pathological features of scce, as well as history, and demographic features we undertook the present investigation. following to the surgical resection tissue samples of the 44 patients with scce was used for e-cadherin promoter methylation examination. analysis was done using methylation specific polymerase chain reaction (ms-pcr). furthermore, for evaluating e-daherin expression levels, reverse transcription pcr (rt-pcr) was applied.results have indicated that twenty four out of the forty four tumor dna samples (54.5%) were aberrantly methylated. in contrast, all normal tissues were found to be unmethylated. in addition a significant association was found between methylation status of e-cadherin promoter with type i and ii of the tumor differentiation (p=0.024), stages t2 and t3 of tumors (p= 0.026), as well as lymph node invasion (p= 0.004). e-cadherin tumor suppressor gene subjects to epigenetic silencing through aberrant promoter cpg islands methylation; a mechanism which is most commonly contributed with the other important tumor suppressor genes in the scce carcinogenesis in the world’s highest risk region for scce.
منابع مشابه
E-cadherin Promoter Methylation Comparison and Correlation with the Pathological Features of the Squamous Cell Carcinoma of Esophagus in the High Risk Region
E-cadherin is among tumor suppressor genes which mostly subjects to the down-regulation in squamous cell carcinoma of esophagus (SCCE). The gene is tightly associated with the tumor invasion and metastasis in multiple human cancers, especially SCCE. CpG islands’ methylation in the promoter region of E-cadherin is among the mechanisms that have been suggested for the E-cadherin silencing, howeve...
متن کاملthe study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولthe relationship between academic self-concept and academic achievement in english and general subjects of the students of high school
according to research, academic self-concept and academic achievement are mutually interdependent. in the present study, the aim was to determine the relationship between the academic self-concept and the academic achievement of students in english as a foreign language and general subjects. the participants were 320 students studying in 4th grade of high school in three cities of noor, nowshah...
the analysis of the role of the speech acts theory in translating and dubbing hollywood films
از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...
15 صفحه اولمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
journal of sciences, islamic republic of iranناشر: university of tehran
ISSN 1016-1104
دوره 25
شماره 1 2014
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023